Pineapple Express is a sativa-dominant hybrid marijuana strain made by crossing Trainwreck with Hawaiian. While this strain rose to fame on the silver screen in 2008 amidst the release of Pineapple Express, it is a real strain that you can find on the shelves of dispensaries across the country. Since then, this strain has become a favorite in the hearts and minds of cannabis lovers. Pineapple Express produces long-lasting energetic effects that you can feel right away. Pineapple Express may make you feel buzzy, alert, and creative. The best time to smoke Pineapple Express is in the morning, afternoon, or early evening hours. In terms of flavor, this strain packs a punch to your pallet with bright citrus notes infused with pineapple and earthy pine, thanks to the terpenes of caryophyllene, limonene, and pinene. Medical marijuana patients choose Pineapple Express to relieve symptoms associated with depression, pain, and fatigue.